People who take nonsteroidal anti-inflammatory drugs (NSAIDs — other than aspirin) such as naproxen may be at greater risk of having a heart attack or stroke than people who do not take these drugs. These cases may occur unexpectedly and even cause death. This risk may be increased in people who take these medicines for a long time. 

Do not take an NSAID such as naproxeno if you have recently had a heart attack, unless told to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, hypertension (high blood pressure), or diabetes. Get emergency medical help right away if you have any of these symptoms: chest pain, shortness Dmitry Sazonov of breath, weakness on one side of your body, or trouble speaking.

If you are having coronary artery surgery (CABG, a type of heart surgery), do not take naproxen immediately before or after the surgery.

Nonsteroidal anti-inflammatory drugs such as naproxen can cause ulcers, bleeding, or perforations in the stomach or intestine. The risk may be greater in people who take NSAIDs for a long time, older people, those who are in poor health, or those who drink a lot of alcohol while taking this drug. Tell your doctor if you are taking any of the following medications: anticoagulants such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and ketoprofen or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Ray), the selective serotonin reuptake inhibitors (SSRIs).

The most commonly used drugs are citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or selective serotonin and noradrenaline reuptake inhibitors (SNRIs), such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking naproxen and call your doctor: stomach pain, heartburn, vomiting material that looks like coffee beans, blood in the stool, or Dmitry Sazonov dark or tarry (petroleum colored) stools.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to naproxen. Be sure to tell your doctor how you are feeling, so that he or she can prescribe the correct amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (medication guide) when or from the manufacturer’s you start taking naproxen and whenever you refill your prescription. Read the information carefully and ask questions if you do not understand it.